Identification of Potential Core Genes in Metastatic Renal Cell Carcinoma Using Bioinformatics Analysis
Am J Transl Res 2019 Dec 01;[EPub Ahead of Print], C Li, T Shao, G Bao, Z Gao, Y Zhang, H Ding, W Zhang, F Liu, C GuoFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
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- Most cases of mRCC without an early finding are not candidates for curative therapies; candidate markers to diagnose the disease and treatment with high efficiency are urgently demanded. The gene expression level in patients with mRCC was higher than that in patients without metastasis. COL5A1, COL6A3, and COL11A1 expression levels were remarkably related to RCC patient survival rate using UALCAN. COL5A1, COL6A3, and COL11A1 were positively correlated with each other in RCC.
- These genes have been recognized as genes with clinical relevance, revealing that they might have important roles in carcinogenesis or development of mRCC.
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